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François MADORE

François Madore

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Directeur de département

Faculté de médecine - Département de médecine

Roger-Gaudry office S-755

f.madore@umontreal.ca

514 343-5931

Professeur titulaire

Faculté de médecine - Département de médecine

f.madore@umontreal.ca

Professeur titulaire

École de santé publique - Département de médecine sociale et préventive

f.madore@umontreal.ca

Travail 1 : 514 343-5931

Travail 2 : 514 338-2222 #2883

Télécopieur : 514 338-2694

MSc
1996 , Épidémiologie et biostatistique , Harvard School of Public Health (États-Unis)

M.D.
1989 , Université de Montréal (Canada)

DES - médecine interne
1992 , Université de Montréal (Canada)

DES - néphrologie
1994 , Université de Montréal (Canada)

Affiliations

  • Membre – CR-HSCM — Centre de recherche de l’Hôpital du Sacré-Cœur de Montréal

Expertises

Responsabilities and outreach Expand all Collapse all

Responsabilités administratives
Activités clinique et professionnelle
Activités au sein d’organismes ou d’entités de l’institution
Expertise professionnelle (hors de l’institution)
Services à la collectivité

Student supervision Expand all Collapse all

La pression artérielle centrale : ses déterminants et son rôle dans la prédiction du risque cardiovasculaire Thèses et mémoires dirigés / 2020 - 2020
Graduate : Lamarche, Florence
Cycle : Master's
Grade : M. Sc.
Thèses et mémoires dirigés
Postdoctorants

Research projects Expand all Collapse all

Redefining blood pressure: How novel views of the arterial tree can lead to better cardiovascular risk stratification. Projet de recherche au Canada / 2020 - 2025

Lead researcher : Rémi Goupil
Co-researchers : François Madore , Annie Claire Nadeau-Fredette , Mohsen Agharazii
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

• Redefining blood pressure: How novel views of the arterial tree can lead to better cardiovascular risk stratification Projet de recherche au Canada / 2020 - 2023

Lead researcher : Rémi Goupil
Co-researchers : Annie Claire Nadeau-Fredette , François Madore , Mohsen Agharazii
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

The molecular heritage of vascular injury: Roles in rejection and renal failure Projet de recherche au Canada / 2016 - 2023

Lead researcher : Marie-Josée Hébert
Co-researchers : Pierre Thibault , François Madore , Héloïse Cardinal
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Aldosterone antagonism and enhanced Clearance for Health Improvement EValuation in End-stage renal disease (ACHIEVE) Trial Projet de recherche au Canada / 2016 - 2022

Lead researcher : Sacha de Serres , Michael William Walsh
Co-researchers : Rita Suri , François Madore
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Impact of Covid-19 on Patients Receiving Hemodialysis: the Quebec Renal Network (QRN) Covid-19 Study Projet de recherche au Canada / 2020 - 2021

Co-researchers : François Madore
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)

The molecular heritage of vascular injury: Roles in rejection and renal failure Projet de recherche au Canada / 2016 - 2021

Co-researchers : Pierre Thibault , Marie-Josée Hébert , François Madore , Héloïse Cardinal
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

SUBVENTION DE CENTRE DE RECHERCHE HOPITAL SACRE-COEŒUR Projet de recherche au Canada / 2013 - 2020

Lead researcher : François Madore
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Subvention de centres de recherche

Protection of the heart with aldosterone antagonism in end-stage renal disease (PHASE 2) Trial Projet de recherche au Canada / 2015 - 2016

Lead researcher : François Madore
Co-researchers : Michael William Walsh
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)

THE CANADIAN KIDNEY KNOWLEDGE TRANSLATION AND GENERATION NETWORK (CANN-NET) Projet de recherche au Canada / 2010 - 2015

Lead researcher : François Madore
Co-researchers : Braden Manns
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(SVB) Subvention catalyseur: équité en matière de santé

SUBVENTION DE CENTRE DE RECHERCHE HOPITAL SACRE-COEUR Projet de recherche au Canada / 2009 - 2012

Lead researcher : François Madore

SOUTIEN A LA DIFFUSION SCIENTIFIQUE - CENTRE DE RECHERCHE DE L'HOPITAL SACRE-COEUR DE MONTREAL Projet de recherche au Canada / 2009 - 2011

Lead researcher : François Madore

NOUVEAUX MARQUEURS DE MALADIE CARDIOVASCULAIRE CHEZ LE SUJET AVEC INSUFFISANCE RENALE CHRONIQUE : IMPACT ET MECANISMES SOUS-JACENTS Projet de recherche au Canada / 2008 - 2011

Co-researchers : François Madore

Publications Expand all Collapse all

  • JC. Verhave, S. Troyanov MD1, F. Mongeau, L. Fradette, J. Bouchard, P. Awadalla, F Madore. Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care. Clin J Am Soc Nephrol. 2014 Apr;9(4):713-9.

  • Manns B, Barrett B, Evans M, Garg A, Hemmelgarn B, Kappel J, Klarenbach S, Madore F, Parfrey P, Samuel S, Soroka S, Suri R, Tonelli M, Wald R, Walsh M, Zappitelli M; CAnadian KidNey KNowledge TraNslation and GEneration NeTwork. Establishing a national knowledge translation and generation network in kidney disease: the CAnadian KidNey KNowledge TraNslation and GEneration NeTwork. Can J Kidney Health Dis. 2014 Apr 7;1:2.

  • Levin A, Rigatto C, Barrett B, Madore F, Muirhead N, Holmes D, Clase CM, Tang M, Djurdjev O. Biomarkers of inflammation, fibrosis, cardiac stretch and injury predict death but not renal replacement therapy at 1 year in a Canadian chronic kidney disease cohort. Nephrol Dial Transplant. 2014 May;29(5):1037-47.

  • Cardinal H, Madore F, Brophy JM, Joseph L, Hébert MJ, Min S, Boyer L, Bogaty P. Longitudinal trends in sFas, a biomarker of apoptosis, after an acute coronary syndrome: clues to the pathogenesis underlying adverse events on follow-up. Int J Cardiol. 2014 May 15;173(3):603-7.

  • Verhave JC, Tagalakis V, Suissa S, Madore F, Hébert MJ, Cardinal H. The risk of thromboembolic events in kidney transplant patients. Kidney Int. 2014 Jun;85(6):1454-60.

  • O'Meara E, Rouleau JL, White M, Roy K, Blondeau L, Ducharme A, Neagoe PE, Sirois MG, Lavoie J, Racine N, Liszkowski M, Madore F, Tardif JC, de Denus S. Heart Failure with Anemia: Novel Findings on the Roles of Renal Disease, Interleukins, and Specific Left Ventricular Remodeling Processes. Circ Heart Fail.  2014 Sep;7(5):773-81.

  • Payette A, Ghannoum M, Madore F, Albert M, Troyanov S, Bouchard. Carbamazepine poisoning treated by multiple extracorporeal treatments. Clin Nephrol. 2015 Mar;83(3):184-8.

  • Akbari A, Clase CM, Acott P, Battistella M, Bello A, Feltmate P, Grill A, Karsanji M, Komenda P, Madore F, Manns BJ, Mahdavi S, Mustafa RA, Smyth A, Welcher ES. Canadian Society of Nephrology Commentary on the KDIGO Clinical Practice Guideline for CKD Evaluation and Management. Am J Kidney Dis. 2015 Feb;65(2):177-205.

  • Madore F. Plasmapheresis in cast nephropathy: yes or no? Curr Opin Nephrol Hypertens. 2015 Mar;24(2):177-182

  • Rigatto C, Walsh M, Zalunardo N, Clase CM, Manns BJ, Madore F, Samuel SM, Morgan CJ, Wolfs W, Suri RS. Establishing a Canadian national clinical trials network for kidney disease: proceedings of a planning workshop. Can J Kidney Health Dis. 2015 Nov 17;2:46.

  • Chiu HH, Tangri N, Djurdjev O, Barrett BJ, Hemmelgarn BR, Madore F, Rigatto C, Muirhead N, Sood MM, Clase CM, Levin A.Perceptions of prognostic risks in chronic kidney disease: a national survey. Can J Kidney Health Dis. 2015 Dec 20;2:53.

  • Troyanov S, Delmas-Frenette C, Bollée G, Youhanna S, Bruat  V, Awadalla P, Devuyst O, Madore F. Clinical, genetic and urinary factors associated with uromodulin excretion. cJASN. 2016 Jan 7;11(1):62-9.

  • Kim RB, Morse BL, Djurdjev O, Tang M, Muirhead N, Barrett B, Holmes DT, Madore F, Clase CM, Rigatto C, Levin A. Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events. Kidney Int. 2016 May;89(5):1144-52.

  • Goupil R, Dupuis D, Agharazii M, Hamet P, Troyanov S, Madore F. Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE. Nephrol Dial Transplant. 2016 Apr 13. [Epub ahead of print].

  • Goupil R, Dupuis D, Troyanov S, Madore F, Agharazii M. Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis. J Hypertens. 2016 Aug;34(8):1535-43.

  • Paquette F, Goupil R, Madore F, Troyanov S, Bouchard J. Continuous venovenous hemofiltration using customized replacement fluid for acute kidney injury with severe hypernatremia Clin Kidney J. 2016 Aug;9(4):540-2.

  • Lepeytre F, Cardinal H, Fradette L, Verhave J, Dorais M, Lelorier J, Pichette V, Madore F. The impact of Renal Protection Clinics on Prescription of and Adherence to Cardioprotective Drug Therapy in Chronic Kidney Disease Patients. Clin Kidney J. 2017 Jun;10(3):375-380.

  • Lepeytre F, Goupil R, Ammann H, Ghannoum M, Troyanov S, Madore F, Bouchard J. Formulas for Calculated Osmolarity and Osmolal Gap: A Study of Diagnostic Accuracy. Am J Kidney Dis. 2017 Sep;70(3):347-356.

  • CREDENCE study investigators. The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics. Am J Nephrol. 2017 Dec 13;46(6):462-472.

  • Lepeytre F, Lavoie PL, Troyanov S, Madore F, Agharazii M, Goupil R. Uric acid association with pulsatile and non-pulsatile components of central and peripheral blood pressures. J Hypertens. 2018 Mar; 36(3):495-501.

  • Lamarche F, Agharazii M, Nadeau-Fredette AC, Madore F, Goupil R. Central and Brachial Blood Pressures, Statins and LDL-cholesterol: A Mediation Analysis. Hypertension. 2018 Mar; 71(3):415-421.

  • Soroka S, Agharazii M, Donnelly S, Roy L, Muirhead N, Cournoyer S, MacKinnon M, Pannu N, Barrett B, Madore F, Tennankore K, Wilson JA, Hilton F, Sherman N, Wolter K, Orazem J, Feugère G. An adjustable dalteparin sodium dose regimen for the prevention of clotting in the extracorporeal circuit during haemodialysis: a clinical trial of safety and efficacy (the PARROT study). Canadian Journal of Kidney Health and Disease, 2018, 5:1-12.

  • Krajcoviechova A, Tremblay J, Awadalla P, Troyanov S, Madore F, Hamet P. Urinary uromodulin in a pathway between decreased urinary uric acid excretion and albuminuria.  J Hypertens, 2018 Dec 14. doi: 10.1093/ajh/hpy190. 

  • Desbiens LC, Goupil R, Madore F, Sidibé A, Mac-Way F. Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey. Osteoporos Int. 2019 Apr;30(4):787-795.

  • Pelletier K, Bonnefoy A, Chapdelaine H, Pichette V, Lejars M, Madore F, Brachemi S, Troyanov S. Clinical Value of Complement Activation Biomarkers in Overt Diabetic Nephropathy. Kidney International Reports, 2019, Vol. 4, Issue 6, p797–805.

  • Paré M, Goupil R, Fortier C, Mac-Way F, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Madore F, Agharazii, M. Determinants of increased central excess pressure in dialysis: role of dialysis modality and arteriovenous fistula. Am J Hypertens, 2019 Aug 17.

  • Desbiens LC, Goupil R, Madore F, Mac-Way F. Incidence of fractures in middle-aged individuals with early CKD: A population-based analysis of CARTaGENE. Neph Dialysis Transplant, 2020 Jan 17.

  • Khalili M, Lepeytre F, Guertin J, Goupil R, Bouchard J, Troyanov S, Madore F. Aspirin for the Primary Prevention of Cardiovascular Disease in the General Population: Impact of Updated Recommendations. CMAJ Open. 2020 Jan 28;8(1): e41-e47.

  • Dupuis ME, Nadeau-Fredette AC, Madore F, Agharazii M, Goupil R. Glomerular hyperfiltration predicts of cardiovascular outcomes in apparently healthy individuals. JAMA Netw Open. 2020;3(4): e202377.

  • Lamarche F, Agharazii M, Madore F, Goupil R. Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure: a Prospective Study. Hypertension (sous presse)

Communications Expand all Collapse all

  • Delmas-Frenette C, Troyanov S, Awadalla P, Devuyst O, Madore F. Predictors of uromodulin excretion: data from the CARTaGENE cohort. Annual Meeting of the Canadian Society of Nephrology, 2015.
  • Dupuis D, Agharazii M, Troyanov S, Awadalla P, Madore F. Central parameters of artrial stiffness and early chronic kidney disease: data from the CARTaGENE cohort. Annual Meeting of the Canadian Society of Nephrology, 2015.
  • Dupuis D, Agharazii M, Troyanov S, Awadalla P, Madore F. Association entre les paramètres centraux de rigidité artérielle et l’insuffisance rénale chronique précoce dans la cohorte CARTaGENE. Congrès annuel de la Société québécoise de néphrologie, Québec, QC. 2015.
  • Bernier-Jean A, Duca A, Madore F, Goupil F, Troyanov S, Bouchard J. Assessment of Methods Used to Substitute for Missing Preadmission Creatinine Values in the Diagnosis and Staging of Acute Kidney Injury. J. Am. Soc. Nephrol. 2015, 26:669A.
  • Goupil R, Dupuis D, Troyanov S, Madore F, Agharazii M. The Detrimental Effects of Beta-Blockers on Central Hemodynamic Parameters: A Propensity Score Analysis. J. Am. Soc. Nephrol. 2015, 26:770A.
  • Lavoie PL, Troyanov S, Madore F, Goupil R. Uric Acid Levels Are Associated with Peripheral but Not Central Blood Pressure Parameters in Normotensive Individuals. J. Am. Soc. Nephrol. 2015, 26:775A.
  • Delmas-Frenette C, Troyanov S, Bouchard J, Goupil F, Madore F. The Impact of Renin-Angiotensin System Blockers on Renal Sodium Handling: An Analysis of CARTaGENE. J. Am. Soc. Nephrol. 2015, 26:776A.
  • Bernier-JeanA, Duca A, Troyanov S, Goupil R, Madore F, Bouchard J. Diagnostic et pronostic de l’insuffisance rénale aiguë selon les méthodes utilisées pour substituer les mesures manquantes de la créatinine de base. Congrès annuel de la Société québécoise de néphrologie, Montréal, QC. 2016.
  • Lepeytre F, Lavoie PL, Troyanov S, Madore F, Goupil R. Uric Acid Levels Are Associated with Peripheral but Not Central Blood Pressure Parameters in Normotensive Individuals. Annual Meeting of the Canadian Society of Nephrology, 2016.
  • Bernier-Jean A, Duca A, Madore F, Goupil F, Troyanov S, Bouchard J. Assessment of Methods Used to Substitute for Missing Preadmission Creatinine Values in the Diagnosis and Staging of Acute Kidney Injury. Annual Meeting of the Canadian Society of Nephrology, 2016.
  • Lepeytre F, Khalili M, Troyanov S, Bouchard J, Madore F. Impact of Updated Recommendations for Aspirin Use for the Primary Prevention of Cardiovascular Disease. J. Am. Soc. Nephrol. 2016, 27:821A.
  • Soroka S, Agharazii M, Donnelly S, Muirhead N, Cournoyer S, MacKinnon M, Barrett B, Madore F, Wilson JA, Hilton F, Kaplan I, Sherman N, Wolter K, Orazem J, Feugère G. Dalteparin sodium for the prevention of clotting of the extracorporeal circuit in hemodialysis: a phase IIIB open-label study to optimize a single-bolus dose - the PARROT study. Annual Meeting of the Canadian Society of Nephrology, 2017, p. 13.
  • Dupuis ME, Lepeytre F, Agharazii M, Madore F, Goupil R.Could an increase in central blood pressures explain renal hyperfiltration in healthy individuals? Annual Meeting of the Canadian Society of Nephrology, 2017, p. 42.
  • Khalili M, Lepeytre F, Troyanov S, Bouchard J, Madore F. Aspirin Use for the Primary Prevention of Cardiovascular Disease in the General Population: Impact of Updated Recommendations. Annual Meeting of the Canadian Society of Nephrology, 2017, p. 133.
  • Dupuis ME, Lepeytre F, Agharazii M, Madore F, Goupil R. L’hyperfiltration rénale est associée à une élévation de la pression centrale chez des individus sains.Société québécoise d’hypertension artérielle. 2017
  • Lepeytre F, Khalili M, Troyanov S, Bouchard J, Madore F. Aspirin Use for the Primary Prevention of Cardiovascular Disease in the General Population and in CKD Patients: Impact of Updated Recommendations. International Society of Nephrology, 2017.
  • Lepeytre F, Goupil R, Ammann H, Ghannoum M, Troyanov S, Madore F, Bouchard J. Revisited formulas for calculated osmolarity and osmolal gap based on a large sample population. International Society of Nephrology, 2017.
  • ME. Dupuis, F. Madore, M. Agharazii, R. Goupil.
  • Soroka S, Agharazii M, Donnelly S, Muirhead N, Cournoyer S, MacKinnon M, Barrett B, Madore F, Wilson JA, Hilton F, Kaplan I, Sherman N, Wolter K, Orazem J, Feugère G. Dalteparin sodium for the prevention of clotting of the extracorporeal circuit in hemodialysis: a phase IIIB open-label study to optimize a single-bolus dose - the PARROT study. Nephrology Dialysis Transplantation 2017, 32 (suppl_3):iii289
  • ME. Dupuis, F. Madore, M. Agharazii, R. Goupil, Pelletier K, Côté AM, Madore F, Goupil R. Pregnancy is associated with higher central systolic and pulse pressures in later life. J. Am. Soc. Nephrol. 2017, 28:546A.
  • Lamarche F, Agharazii M, Madore F, Goupil R. Central Blood Pressure, Statins, and LDL-cholestrol: A Mediation Analysis. J. Am. Soc. Nephrol. 2017, 28:450A.
  • Dupuis ME, Madore F, Agharazii M, Goupil R. Renal hyperfiltration and Central Blood Pressures: a populational cohort study. J. Am. Soc. Nephrol. 2017, 28:216A.
  • Desbiens LC, Goupil R, Madore F, Sidibé A, Mac-Way F. Risk factors of fractures in patients with stage 3 CKD: analysis of CARTaGENE. J. Am. Soc. Nephrol. 2017, 28:5910A.
  • Krajcoviechova A, Marois-Blanchet FC, Troyanov S, Harvey F, Dumas P, Tremblay J, Cifkova R, Awadalla P, Madore F, Hamet P. Urinary uromodulin in a pathway between decreased urinary uric acid excretion and albuminuria. J Hypertens, Vol 36, suppl e119, 2018.
  • Pelletier K, Bonnefoy A, Chapdelaine H, Pichette V, Lejars M, Madore F, Brachemi S, Troyanov S. Clinical value of urinary C5b-9 complement complex in overt diabetic nephropathy. J. Am. Soc. Nephrol. 2018, 29: 538A.
  • Genest DS, Gosselin N, Goupil R, Bouchard J, Troyanov S, Madore F. Association between eGFR and cognitive performance. J. Am. Soc. Nephrol. 2018, 29:920A.
  • Genest DS, Khalili M, Goupil R, Bernier-Jean A, Bouchard J, Troyanov S, Madore F. Association between healthy diet score and kidney function: a cross-sectional study. J. Am. Soc. Nephrol. 2018, 29:1011A.
  • Desbiens LC, Goupil R, Madore F, Mac-Way F. Bone Mineral Density and Handgrip Strength in Early CKD: Cross-Sectional Analysis of CARTaGENE. J. Am. Soc. Nephrol. 2018, 29: 905A.
  • Genest DS, Bernier-Jean A, Khalili M, Goupil R, Bouchard J, Troyanov S, Madore F. Healthy diet score and kidney function: a cross-sectional study. International Society of Nephrology, 2019.
  • Paramètres artériels périphériques, centraux et fractures: Analyse de CARTaGENE. Desbiens LC, Goupil R, Madore F, Agharazii M, Mac-Way F. Société québécoise d’hypertension artérielle. 2019.
  • Desbiens LC, Goupil R, Madore F, Mac-Way F. The burden of fractures in mild chronic kidney disease. Nephrology Dialysis Transplantation, 2019, 34 (suppl 1): i448.

  • Desbiens LC, Goupil R, Madore F, Mac-Way F. Quantitative ultrasound and fractures in early CKD: analysis of CARTaGENE. Nephrology Dialysis Transplantation, 2019, 34 (suppl 1): i347-348.

  • Dupuis ME, Nadeau-Fredette AC, Madore F, Agharazii M, Goupil R. Glomerular Hyperfiltration Predicts Cardiovascular Outcomes in Apparently Healthy Individuals. J. Am. Soc. Nephrol. 2019, 30: 14.

  • Lamarche F, Agharazii M, Madore F, Goupil R. Hypertension Is Associated with Adverse Cardiovascular Outcomes Only When Both Brachial and Central Blood Pressures Are Elevated. J. Am. Soc. Nephrol. 2019, 30: 297.

  • Lamarche F, Desbiens LC, Mac-Way F, Agharazii M, Madore F, Goupil R. Central Systolic and Pulse Pressures as Predictors of Cardiovascular Events: A Prospective Study. J. Am. Soc. Nephrol. 2019, 30: 999.

  • Goupil R, Nadeau-Fredette AC, Beaubien-Souligny W, Madore F, Suri RS. Accuracy of lower temperature thresholds in detecting COVID-19 in hemodialysis patients. J. Am. Soc. Nephrol. 2020, 31: 271.

  • Jutras G, Genest D, Bernier-Jean A, Goupil R, Madore F. Dietary Fiber Intake, Cardiovascular Risk Factors and Kidney Function: a Mediation Analysis. J. Am. Soc. Nephrol. 2020. 31: 624.

  • Murdoch A, Madore F, Sparkes D, Tennankore K, Vorster H, Suri R. A New Vision for Nephrology Trials in Canada. J. Am. Soc. Nephrol. 2020, 31: 224.

Additional Information

Media

| FRQS | Améliorer le traitement des traumatismes de la moelle épinière | François Madore

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