Marie-Pierre Dubé
- Professeure titulaire
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Faculté de médecine - Département de médecine
- Professeure titulaire
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École de santé publique - Département de médecine sociale et préventive
- Professeure accréditée
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Faculté de médecine - Département de biochimie et médecine moléculaire
- Professeure accréditée
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Faculté de médecine - Département de pharmacologie et physiologie
Courriels
marie-pierre.dube@pgx.ca (Travail)
Marie-Pierre.Dube@statgen.org (Travail)
Travail 1 : 514 670-7670 #7701
Travail 2 : 514 376-3330 #2298
Télécopieur : 514 376-1355
Web : Site web de l’unité de recherche
Web : PubMed
Web : LinkedIn
Web : Google Scholar
Doctorat
2000
, Génétique , Université McGill (Canada)
Baccalauréat
1994
, Biologie et autres sciences connexes , Université McGill (Canada)
Postdoctorat
2001
, Épidémiologie et biostatistique , University of Toronto (Canada)
Affiliated institutions
Institut de cardiologie de Montréal (ICM)
Affiliations
- Titulaire – Chaire de recherche du Canada en analyse des données pour la médecine de précision
- Membre – ICM — Centre de recherche de l'Institut de cardiologie de Montréal
Education Programs
- Fundamental and Applied Sciences Health Sciences Life Sciences
- Fundamental and Applied Sciences Health Sciences
- Health Sciences Life Sciences Fundamental and Applied Sciences
- Fundamental and Applied Sciences Health Sciences Life Sciences
- Health Sciences Life Sciences Fundamental and Applied Sciences
- Health Sciences Life Sciences
- Health Sciences Life Sciences
- Health Sciences
- Health Sciences Environment and Sustainable Development
- Health Sciences Environment and Sustainable Development
- Health Sciences Environment and Sustainable Development
- Health Sciences Environment and Sustainable Development
- PhD in Pharmacology – Health Sciences Life Sciences
- Health Sciences
Courses
- MSO6018 Introduction à l'épidémiologie génétique
Expertises
- Genetics
- Genomics
- Optimal drug use
- Cardiovascular Diseases
- Pharmacoepidemiology
- Sex and gender
Genetic epidemiology studies of cardiovascular disease and pharmacogenomics, including specific studies on statins and anticoagulants. We also conduct statistical genetic studies on gene-environment interactions and population stratification.
Student supervision Expand all Collapse all
Cycle : Master's
Grade : M. Sc.
Cycle : Doctoral
Grade : Ph. D.
Research projects Expand all Collapse all
Study of sex-specific biological factors underlying cognitive function and cardiovascular outcomes Projet de recherche au Canada / 2022 - 2028
Precision medicine study of treatment options in type 2 diabetes patients without cardiovascular disease Projet de recherche au Canada / 2022 - 2028
Precision medicine study of type 2 diabetes in the COLCOT-T2D trial Projet de recherche au Canada / 2022 - 2028
Precision medicine study of type 2 diabetes in the COLCOT-T2D trial Projet de recherche au Canada / 2022 - 2027
Canada Research Chair in Precision Medicine Data Analysis Projet de recherche au Canada / 2020 - 2027
COLCOT-T2D : Colchicine for Primary Prevention of Cardiovascular Events in Patients with Type 2 Diabetes Projet de recherche au Canada / 2020 - 2027
Study of the effect of sex on drugs dosing, concentrations and pharmacogenomics Projet de recherche au Canada / 2020 - 2026
Precision medicine in diabetes: Pharmacogenetic studies of large randomised controlled trials of diabetes therapies. (MRC PA: Ewan Pearson) Projet de recherche au Canada / 2020 - 2024
Determining the etiologies of age-related clonal hematopoiesis (ARCH), a new biomarker of cancer and cardiovascular disease development: focus on the roles of inflammation and genetic predisposition. Projet de recherche au Canada / 2019 - 2024
Mendelian randomization study of CETP and ADCY9 in cardiovascular disease Projet de recherche au Canada / 2019 - 2022
Recherche en médecine de précision portant sur le diabète et les maladies cardiovasculaires Projet de recherche au Canada / 2019 - 2020
Effectiveness and safety of Direct Oral AntiCoagulants (DOACs) among older adults with atrial fibrillation Projet de recherche au Canada / 2017 - 2020
Sex differences in the treatment of heart failure Projet de recherche au Canada / 2017 - 2019
PSYCHOLOGICAL BURDEN AND PATHOLOGICAL AGING IN INDIVIDUALS WITH AND WITHOUT CARDIOVASCULAR DISEASE Projet de recherche au Canada / 2010 - 2019
Colchicine Cardiovascular Outcomes Trial Projet de recherche au Canada / 2017 - 2018
Programme ARTERIA: Personnalisation des diagnostics et thérapies cardiovasculaires Projet de recherche au Canada / 2014 - 2018
INCREASING VITAMIN K INTAKE TO IMPROVE LONG-TERM ANTICOAGULATION STABILITY IN PATIENTS TREATED WITH WARFARIN Projet de recherche au Canada / 2013 - 2018
PHARMACOGENOMIC TESTING OF ATORVASTATIN EFFICACY AND TOXICITY IN SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES Projet de recherche au Canada / 2013 - 2018
Colchicine Cardiovascular Outcomes Trial Projet de recherche au Canada / 2016 - 2017
Études pharmacogénomiques vers une thérapie personnalisée en cardiologie Projet de recherche au Canada / 2015 - 2017
Increased risk of cardiovascular disease in women with inherited chromosomally-integrated human herpesvirus 6 Projet de recherche au Canada / 2015 - 2017
Personalized medicine strategies for molecular diagnostics and targeted therapeutics of cardiovascular diseases Projet de recherche au Canada / 2013 - 2017
GENOMIC STUDY OF BLEEDING RISK WITH WARFARIN Projet de recherche au Canada / 2013 - 2017
PERSONALIZED MEDECINE STRATEGIES FOR MOLECULAR DIAGNOSTICS AND TARGETED THERAPEUTICS OF CARDIOVASCULAR DISEASES Projet de recherche au Canada / 2013 - 2017
Integrative genomic and genetic analyses of consanguineous Pakistani pedigrees aggregated with psychotic/affective disorders Projet de recherche au Canada / 2011 - 2017
Développement d'un panel pharmacogénomique et élaboration d'une base de données translationnelle Projet de recherche au Canada / 2015 - 2016
(Bourse Michel Cameron) Développement d'un panel pharmacogénomique et élaboration d'une base de données translationnelle Projet de recherche au Canada / 2015 - 2016
Pharmacogenomic testing of atorvastatin efficacy and toxicity in secondary prevention of cardiovascular diseases Projet de recherche au Canada / 2013 - 2016
NOVEL APPROACHES TO THE PREDICTION, DIAGNOSIS AND TREATMENT OF CARDIAC LATE EFFECTS IN SURVIVORS OF CHILDHOOD CANCER Projet de recherche au Canada / 2011 - 2016
PHARMACOGENETIC STUDY OF WARFARIN Projet de recherche au Canada / 2009 - 2014
EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE Projet de recherche au Canada / 2009 - 2014
Pharmacogenetic Study of Warfarin: Identification of patients on blood-thinner therapy who are at risk of serious adverse events Projet de recherche au Canada / 2009 - 2013
GENETIQUE EPIDEMIOLOGIQUE ET STATISTIQUE Projet de recherche au Canada / 2005 - 2013
Publications Expand all Collapse all
Articles choisis
(étudiants; employés§)
- Sun M, Cyr M-C§, Sandoval J§, Lemieux-Perreault L-P§, Busque L, Tardif J-C, Dubé MP. Somatic mosaic chromosomal alterations and death of cardiovascular disease causes among cancer survivors: an analysis of the UK Biobank. medRxiv. 2022:2022.08.20.22279019, pending publication
- Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial. Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Mooser V, Waters DD, Grégoire JC, L'Allier PL, Jukema WJ, White HD, Heinonen T, Black DM, Laghrissi-Thode F, Levesque S, Guertin MC, Dubé MP; dal-GenE Investigators. Eur Heart J. 2022 Jul 20:ehac374. PMID: 35856777
- Including diverse and admixed populations in genetic epidemiology research. Caliebe A, Tekola-Ayele F, Darst BF, Wang X, Song YE, Gui J, Sebro RA, Balding DJ, Saad M, Dubé MP; IGES ELSI Committee. Genet Epidemiol. 2022 Jul 16. PMID: 35842778
- Pharmacogenomic study of heart failure and candesartan response from the CHARM programme. Dubé MP, Chazara O, Lemaçon A, Asselin G§, Provost S§, Barhdadi A§, Lemieux Perreault LP§, Mongrain I§, Wang Q, Carss K, Paul DS, Cunningham JW, Rouleau J, Solomon SD, McMurray JJV, Yusuf S, Granger CB, Haefliger C, de Denus S, Tardif JC. ESC Heart Fail. 2022 Jun 23. doi: 10.1002/ehf2.14026. PMID: 35736394
- ExPheWas: a platform for cis-Mendelian randomization and gene-based association scans. Legault MA, Lemieux Perreault LP§, Tardif JC, Dubé MP. Nucleic Acids Res. 2022 Apr
- Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction. Levinsson A, de Denus S, Sandoval J§, Lemieux Perreault LP§, Rouleau J, Tardif JC, Hussin J, Dubé MP. Sci Rep. 2022 Feb 2;12(1):1780. PMID: 35110607
- Genetics of symptom remission in outpatients with COVID-19. Dubé MP, Lemacon A, Barhdadi A§, Lemieux Perreault L-P§, Oussaid E§, Asselin G§, Provost S§, Sun M, Sandoval J§, Legault MA, Mongrain I§, Dubois A§, Valois D§, Dedelis E§, Lousky J§, Choi J§, Goulet E, Savard C, Chicoine L-M, Cossette M, Chabot-Blanchet M, Guertin M-C, de Denus S, Bouabdallaoui N, Marchand R, Bassevitch Z, Nozza A, Gaudet D, Allier PL, Hussin J, Boivin G, Busseuil D, Tardif J-C. Sci Rep. 2021 May 25;11(1):10847. PMID: 34035401
- Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT. Dubé MP, Legault MA, Lemaçon A, Lemieux Perreault LP§, Fouodjio R§, Waters DD, Kouz S, Pinto FJ, Maggioni AP, Diaz R, Berry C, Koenig W, Lopez-Sendon J, Gamra H, Kiwan GS, Asselin G§, Provost S§, Barhdadi A§, Sun M, Cossette M, Blondeau L, Mongrain I§, Dubois A§, Rhainds D, Bouabdallaoui N, Samuel M, de Denus S, L'Allier PL, Guertin MC, Roubille F, Tardif JC. Circ Genom Precis Med. 2021 Apr;14(2):e003183. PMID: 33560138
- A genetic model of ivabradine recapitulates results from randomized clinical trials. Legault MA, Sandoval J§, Provost S§, Barhdadi A§, Lemieux Perreault LP§, Shah S, Lumbers RT, de Denus S, Tyl B, Tardif JC, Dubé MP. PLoS One. 2020 Jul 21;15(7):e0236193. PMID: 32692755
- High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential. Busque L*, Sun M, Buscarlet M, Ayachi S, Feroz Zada Y§, Provost S§, Bourgoin V, Mollica L, Meisel M, Hinterleitner R, Jabri B, Dubé MP*, Tardif JC*. Blood Adv. 2020 Jun 9;4(11):2430-2438. PMID: 32492156 (* corresponding authors)
- Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data. Patel RS, et al. Circ Genom Precis Med. 2019 Apr;12(4):e002471. PMID: 30897348
- Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium. Patel R, et al. Circ Genom Precis Med. 2019 Apr;12(4):e002470. PMID: 30896328
- Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort. Shahabi P, Lamothe F§, Dumas S, Rouleau-Mailloux É, Feroz Zada Y§, Provost S§, Asselin G§, Mongrain I§, Valois D§, Gaulin Marion MJ§, Lemieux Perreault LP§, Perreault S, Dubé MP. Pharmacogenomics J. 2019 Apr;19(2):147-156. PMID: 29298995
- Pharmacogenetic content of commercial genome-wide genotyping arrays. Lemieux Perreault LP§, Zaïd N, Cameron M, Mongrain I§, Dubé MP. Pharmacogenomics. 2018 Oct;19(15):1159-1167. Epub 2018 Oct 1. PMID: 30272537
- Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines. Levinsson A, Dubé MP*, Tardif JC, de Denus S. ESC Heart Fail. 2018 Oct;5(5):745-754. PMID: 29916560 (*corresponding author)
- Pharmacogenomics of blood lipid regulation. Legault MA, Tardif JC, Dubé MP. Pharmacogenomics. 2018 May;19(7):651-665. PMID: 29706123
- Rationale, design and preliminary results of the Quebec Warfarin Cohort Study. Perreault S, Shahabi P, Côté R, Dumas S, Rouleau-Mailloux É, Feroz Zada Y§, Provost S§, Mongrain I§, Dorais M, Huynh T, Kouz S, Diaz A, Blostein M, de Denus S, Turgeon J, Ginsberg J, Lelorier J, Lalonde L, Busque L, Kassis J, Talajic M, Tardif JC, Dubé MP. Clin Cardiol. 2018 May;41(5):576-585 PMID: 29542828
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, et al. Nat Genet. 2018 Jan;50(1):26-41. PMID: 29273807
- Exome-wide association study of plasma lipids in >300,000 individuals. Liu DJ, et al. Nat Genet. 2017 Dec;49(12):1758-1766, PMID: 29083408
- CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. de Denus S, Rouleau JL, Mann DL, Huggins GS, Pereira NL, Shah SH, Cappola TP, Fouodjio R§, Mongrain I§, Dubé MP. Pharmacogenomics J. 2018 Apr;18(2) :232-237. PMID: 28440343
- CETP: Pharmacogenomics-Based Response to the CETP Inhibitor Dalcetrapib. Tardif JC, Rhainds D, Rhéaume E, Dubé MP. Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):396-400. PMID: 28126828
- genipe: An automated genome-wide imputation pipeline with automatic reporting and statistical tools. Lemieux Perreault LP§, Legault MA, Asselin G§, Dubé MP. Bioinformatics. 2016, 32(23): 3661-3663 PMID: 27497439
- Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Postmus I, et al. J Med Genet. 2016 Dec;53(12):835-845. PMID: 27587472
- Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance with Clinical Outcomes. Tardif JC, Rhainds D, Brodeur M, Feroz Zada Y§, Fouodjio R§, Provost S§, Boulé M, Alem S, Grégoire JC, L'Allier PL, Ibrahim R, Guertin MC, Mongrain I§, Olsson AG, Schwartz GG, Rhéaume É, Dubé MP. Circ Cardiovasc Genet. 2016 Aug;9(4):340-8. PMID: 27418594
- Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. Myocardial Infarction Genetics CARDIoGRAM Exome Consortia Investigators. New England Journal of Medicine, March 24; 374(12):1134-44, 2016. PMID: 26934567
- Impact of regular physical activity on weekly warfarin dose requirement. Rouleau-Mailloux É, Shahabi P, Dumas S, Feroz Zada Y§, Provost S§, Hu J, Nguyen J, Bouchama N, Mongrain I§, Talajic M, Tardif JC, Perreault S, Dubé MP. J Thromb Thrombolysis. 2016 Feb;41(2):328-35, PMID: 26238769
- Pharmacogenomic Determinants of the Cardiovascular Effects of Dalcetrapib. Tardif JC, Rhéaume E, Lemieux Perreault LP, Grégoire JC, Feroz Zada Y§, Asselin G§, Provost S§, Barhdadi A§, Rhainds D, L’Allier PL, Ibrahim R, Upmanyu R, Niesor EJ, Benghozi R, Suchankova G, Laghrissi-Thode F, Guertin MC, Olsson AG, Mongrain I§, Schwartz GG, Dubé MP. Circ Cardiovasc Genet, 2015 Apr;8(2):372-82; PMID: 25583994
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Postmus I, et al. Nat Commun 2014 Oct 28;5:5068. PMID: 25350695
- CKM and LILRB5 are associated with serum levels of creatine kinase in statin users. Dubé MP, Zetler R, Barhdadi A§, Brown A, Mongrain I§, Normand V§, Laplante N, Asselin G§, Feroz Zada Y§, Provost S§, deDenus S, Turgeon J, Réhaume E, Phillips MS, Tardif JC. Circ Cardiovasc Genet. 2014 Dec;7(6):880-6. PMID: 25214527
- Comparison of genotype clustering tools with rare variants. Lemieux Perreault LP, Legault MA, Barhdadi A§, Provost S§, Normand V§, Tardif JC, Dubé MP. BMC Bioinformatics. 2014 Feb 21;15(1):52. PMID: 24559245
- Validation of warfarin pharmacogenetic algorithms in clinical practice. Marin-Leblanc M, Perreault S, Bahroun I, Lapointe M, Mongrain I§, Provost S§, Turgeon J, Talajic M, Brugada R, Phillips M, Tardif JC, Dubé MP. Pharmacogenomics. 2012 Jan;13(1):21-9. PMID: 22176621
- Partitioning of copy-number genotypes in pedigrees. Lemieux Perreault LP, Andelfinger G, Asselin G§, Dubé MP. BMC Bioinformatics 2010, 11:226. PMID: 20438641
- Testing for Gene-Gene Interaction with AMMI Models. Barhdadi A, Dubé MP. Statistical Applications in Genetics and Molecular Biology 2010, Vol. 9:Iss. 1, Article 2. PMID: 20196752
- Application of Homozygosity Haplotype Analysis to Genetic Mapping with High-Density SNP Genotype Data. Jiang H, Orr A, Guernsey DL, Robitaille J, Asselin G§, Samuels ME, Dubé MP. PLoS ONE 2009; 4(4):e5280. Apr 28. PMID: 19399176
- Genetic predictors of depressive symptoms in cardiac patients. McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lespérance F, Théroux P, Rouleau GA, Dubé MP. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5; 150B(3):381-8. PMID: 18618671
Additional Information
- Équipe de recherche de Marie-Pierre Dubé
- Centre de Pharmacogénomique Beaulieu-Saucier de l'Université de Montréal
- Portrait de chercheur - Marie-Pierre Dubé : une femme de défis
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Alcool et génétique
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