Marie-Pierre DUBÉ
Marie-Pierre Dubé
- Professeure titulaire
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Faculté de médecine - Département de médecine
- Professeure titulaire
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École de santé publique - Département de médecine sociale et préventive
- Professeure accréditée
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Faculté de médecine - Département de biochimie et médecine moléculaire
- Professeure accréditée
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Faculté de médecine - Département de pharmacologie et physiologie
Courriels
marie-pierre.dube@pgx.ca (Travail)
Marie-Pierre.Dube@mhi-rc.org (Travail)
Travail 1 : 514 670-7670 #7701
Travail 2 : 514 376-3330 #2298
Télécopieur : 514 376-1355
Web : Site web de l’unité de recherche
Web : PubMed
Web : LinkedIn
Web : Google Scholar
Doctorat
2000
, Génétique , Université McGill (Canada)
Baccalauréat
1994
, Biologie et autres sciences connexes , Université McGill (Canada)
Postdoctorat
2001
, Épidémiologie et biostatistique , University of Toronto (Canada)
Affiliated institutions
Institut de cardiologie de Montréal (ICM)
Affiliations
- Titulaire – Chaire de recherche du Canada en analyse des données pour la médecine de précision
- Membre – ICM — Centre de recherche de l'Institut de cardiologie de Montréal
Expertises
- Genetics
- Genomics
- Optimal drug use
- Gene Therapy
- Cardiovascular Diseases
Genetic epidemiology studies of cardiovascular disease and pharmacogenomics, including specific studies on statins and anticoagulants. We also conduct statistical genetic studies on gene-environment interactions and population stratification.
Student supervision Expand all Collapse all
Cycle : Master's
Grade : M. Sc.
Cycle : Doctoral
Grade : Ph. D.
Research projects Expand all Collapse all
Precision medicine study of treatment options in type 2 diabetes patients without cardiovascular disease Projet de recherche au Canada / 2022 - 2028
Precision medicine study of type 2 diabetes in the COLCOT-T2D trial Projet de recherche au Canada / 2022 - 2028
Precision medicine study of type 2 diabetes in the COLCOT-T2D trial Projet de recherche au Canada / 2022 - 2027
Canada Research Chair in Precision Medicine Data Analysis Projet de recherche au Canada / 2020 - 2027
COLCOT-T2D : Colchicine for Primary Prevention of Cardiovascular Events in Patients with Type 2 Diabetes Projet de recherche au Canada / 2020 - 2027
Complex genetics of hypertrophic cardiomyopathy: Towards an integration of polygenic risk in clinical care Projet de recherche au Canada / 2020 - 2026
Study of the effect of sex on drugs dosing, concentrations and pharmacogenomics Projet de recherche au Canada / 2020 - 2026
Comparing the effects of cognitive training and physical exercise on cognition, cerebral autoregulation and cerebral vasoreactivity in men and women with heart failure Projet de recherche au Canada / 2019 - 2025
Precision medicine in diabetes: Pharmacogenetic studies of large randomised controlled trials of diabetes therapies. (MRC PA: Ewan Pearson) Projet de recherche au Canada / 2020 - 2024
Determining the etiologies of age-related clonal hematopoiesis (ARCH), a new biomarker of cancer and cardiovascular disease development: focus on the roles of inflammation and genetic predisposition. Projet de recherche au Canada / 2019 - 2024
Mendelian randomization study of CETP and ADCY9 in cardiovascular disease Projet de recherche au Canada / 2019 - 2022
Développement d'un modèle de prédiction pour optimiser l'usage des anticoagulants oraux (DOACs) en pratique clinique. Demande en évaluation à la Fondation des maladies du coeur et des accidents cérébr.. / Réseau québécois de recherche sur les médicaments Projet de recherche au Canada / 2017 - 2022
Recherche en médecine de précision portant sur le diabète et les maladies cardiovasculaires Projet de recherche au Canada / 2019 - 2020
Effectiveness and safety of Direct Oral AntiCoagulants (DOACs) among older adults with atrial fibrillation Projet de recherche au Canada / 2017 - 2020
Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases Projet de recherche au Canada / 2016 - 2020
Infléchir l'athérosclérose par la médecine de precision. Projet de recherche au Canada / 2018 - 2019
Sex differences in the treatment of heart failure Projet de recherche au Canada / 2017 - 2019
Suvention FICM 2015-2018 Projet de recherche au Canada / 2015 - 2019
PSYCHOLOGICAL BURDEN AND PATHOLOGICAL AGING IN INDIVIDUALS WITH AND WITHOUT CARDIOVASCULAR DISEASE Projet de recherche au Canada / 2010 - 2019
Colchicine Cardiovascular Outcomes Trial Projet de recherche au Canada / 2017 - 2018
Increased risk of cardiovascular disease in women with inherited chromosomally-integrated human herpesvirus 6 Projet de recherche au Canada / 2016 - 2018
Programme ARTERIA: Personnalisation des diagnostics et thérapies cardiovasculaires Projet de recherche au Canada / 2014 - 2018
INCREASING VITAMIN K INTAKE TO IMPROVE LONG-TERM ANTICOAGULATION STABILITY IN PATIENTS TREATED WITH WARFARIN Projet de recherche au Canada / 2013 - 2018
PHARMACOGENOMIC TESTING OF ATORVASTATIN EFFICACY AND TOXICITY IN SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES Projet de recherche au Canada / 2013 - 2018
Colchicine Cardiovascular Outcomes Trial Projet de recherche au Canada / 2016 - 2017
Études pharmacogénomiques vers une thérapie personnalisée en cardiologie Projet de recherche au Canada / 2015 - 2017
Increased risk of cardiovascular disease in women with inherited chromosomally-integrated human herpesvirus 6 Projet de recherche au Canada / 2015 - 2017
Personalized medicine strategies for molecular diagnostics and targeted therapeutics of cardiovascular diseases Projet de recherche au Canada / 2013 - 2017
PERSONALIZED MEDECINE STRATEGIES FOR MOLECULAR DIAGNOSTICS AND TARGETED THERAPEUTICS OF CARDIOVASCULAR DISEASES Projet de recherche au Canada / 2013 - 2017
PERSONALIZED MEDECINE STRATEGIES FOR MOLECULAR DIAGNOSTICS AND TARGETED THERAPEUTICS OF CARDIOVASCULAR DISEASES Projet de recherche au Canada / 2013 - 2017
GENOMIC STUDY OF BLEEDING RISK WITH WARFARIN Projet de recherche au Canada / 2013 - 2017
Integrative genomic and genetic analyses of consanguineous Pakistani pedigrees aggregated with psychotic/affective disorders Projet de recherche au Canada / 2011 - 2017
Développement d'un panel pharmacogénomique et élaboration d'une base de données translationnelle Projet de recherche au Canada / 2015 - 2016
(Bourse Michel Cameron) Développement d'un panel pharmacogénomique et élaboration d'une base de données translationnelle Projet de recherche au Canada / 2015 - 2016
Pharmacogenomic testing of atorvastatin efficacy and toxicity in secondary prevention of cardiovascular diseases Projet de recherche au Canada / 2013 - 2016
NOVEL APPROACHES TO THE PREDICTION, DIAGNOSIS AND TREATMENT OF CARDIAC LATE EFFECTS IN SURVIVORS OF CHILDHOOD CANCER Projet de recherche au Canada / 2011 - 2016
(RESEAUTETE) - THE INTEGRATED RESEARCH NETWORK ON PERINATOLOGY Projet de recherche au Canada / 2008 - 2016
SUBVENTION FICM 2013-2014 Projet de recherche au Canada / 2013 - 2015
PHARMACOGENETIC STUDY OF WARFARIN Projet de recherche au Canada / 2009 - 2014
EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE Projet de recherche au Canada / 2009 - 2014
Pharmacogenetic Study of Warfarin: Identification of patients on blood-thinner therapy who are at risk of serious adverse events Projet de recherche au Canada / 2009 - 2013
EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE Projet de recherche au Canada / 2008 - 2013
GENETIQUE EPIDEMIOLOGIQUE ET STATISTIQUE Projet de recherche au Canada / 2005 - 2013
Publications Expand all Collapse all
Articles choisis
(* étudiant ou membre de l'équipe de recherche)
- Genetics of symptom remission in outpatients with COVID-19. Dubé M-P, Lemacon A*, Barhdadi A*, Lemieux Perreault L-P*, Oussaid E*, Asselin G*, Provost S*, Sun M*, Sandoval J*, Legault M-A*, Mongrain I*, Dubois A*, Valois D*, Dedelis E*, Lousky J*, Choi J*, Goulet E, Savard C, Chicoine L-M, Cossette M, Chabot-Blanchet M, Guertin M-C, de Denus S, Bouabdallaoui N, Marchand R, Bassevitch Z, Nozza A, Gaudet D, Allier PL, Hussin J, Boivin G, Busseuil D, Tardif J-C. Sci Rep. 2021 May 25;11(1):10847. PMID: 3403540
- Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.Sun M*, Lemaçon A*, Legault M-A*, Asselin G*, Provost S*, Aschard H, Barhdadi A*, Zada YF*, Valois D*, Mongrain I*, Tardif J-C, Dubé M-P. The Pharmacogenomics Journal. 2021. PMID: 33649522
- Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT. Dubé MP, Legault MA*, Lemaçon A*, Lemieux Perreault LP*, Fouodjio R*, Waters DD, Kouz S, Pinto FJ, Maggioni AP, Diaz R, Berry C, Koenig W, Lopez-Sendon J, Gamra H, Kiwan GS, Asselin G*, Provost S*, Barhdadi A*, Sun M*, Cossette M, Blondeau L, Mongrain I*, Dubois A*, Rhainds D, Bouabdallaoui N, Samuel M, de Denus S, L'Allier PL, Guertin MC, Roubille F, Tardif JC. Circ Genom Precis Med. 2021 Feb 9. PMID: 33560138
- A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy. de Denus S, Mottet F, Korol S, Feroz Zada Y*, Provost S*, Mongrain I*, Asselin G*, Oussaïd E*, Busseuil D, Lettre G, Rioux J, Racine N, O'Meara E, White M, Rouleau J, Tardif JC, Dubé MP. ESC Heart Fail. 2020 Sep 1. doi: 10.1002/ehf2.12934. Online ahead of print. PMID: 32869539
- A genetic model of ivabradine recapitulates results from randomized clinical trials. MA Legault, J Sandoval, S Provost, A Barhdadi, LP Lemieux Perreault, S Shah, RT Lumbers, S de Denus, B Tyl, JC Tardif, Dubé MP, PLoS One. 2020 Jul 21;15(7):e0236193. PMID: 32692755
- High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential. Busque L, Sun M, Buscarlet M, Ayachi S, Feroz Zada Y, Provost S, Bourgoin V, Mollica L, Meisel M, Hinterleitner R, Jabri B, Dubé MP†, Tardif JC†. Blood Adv. 2020 Jun 9;4(11):2430-2438. PMID: 32492156
- Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib. Tardif JC, Dubé MP, Pfeffer MA, Waters DD, Koenig W, Maggioni AP, McMurray JJV, Mooser V, White HD, Heinonen T, Black DM, Guertin MC; dal-GenE Investigators. Am Heart J 2020 Jan 17;222:157-165. PMID: 32087417
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, Pinto FJ, Ibrahim R, Gamra H, Kiwan GS, Berry C, López-Sendón J, Ostadal P, Koenig W, Angoulvant D, Grégoire JC, Lavoie MA, Dubé MP, Rhainds D, Provencher M, Blondeau L, Orfanos A, L'Allier PL, Guertin MC, Roubille F. N Engl J Med. 2019 Dec 26;381(26):2497-2505. PMID: 31733140
- Lipoprotein (a), arterial inflammation, and PCSK9 inhibition. Tardif JC, Rhéaume E, Rhainds D, Dubé MP. Eur Heart J. 2019 Sep 1;40(33):2782-2784. PMID: 30838412
- Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data. Patel RS, …, Asselbergs FW. Circ Genom Precis Med. 2019 Apr;12(4):e002471. PMID: 30897348
- Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium. Patel R, …, Asselbergs FW. Circ Genom Precis Med. 2019 Apr;12(4):e002470. PMID: 30896328
- Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort. Shahabi P*, Lamothe F*, Dumas S*, Rouleau-Mailloux É*, Feroz Zada Y*, Provost S*, Asselin G*, Mongrain I*, Valois D*, Gaulin Marion MJ*, Lemieux Perreault LP*, Perreault S, Dubé MP. Pharmacogenomics J. 2019 Apr;19(2):147-156. PMID: 29298995
- Pharmacogenetic content of commercial genome-wide genotyping arrays. Lemieux Perreault LP*, Zaïd N*, Cameron M*, Mongrain I*, Dubé MP. Pharmacogenomics. 2018 Oct;19(15):1159-1167. Epub 2018 Oct 1. PMID: 30272537
- Randomized Clinical Trial Needed to Confirm Whether Dalcetrapib Improves Outcomes for Specific ADCY9 Genotype. Pfeffer MA, Dubé MP, Tardif JC. JAMA Cardiol. 2018 Sep 1;3(9):897.. PMID: 30090919
- Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines. Levinsson A*, Dubé MP†, Tardif JC, de Denus S†. ESC Heart Fail. 2018 Oct;5(5):745-754. Review. PMID: 29916560
- Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A. Buscarlet M, Provost S*, Feroz Zada Y*, Bourgoin V, Mollica L, Dubé MP, Busque L. Blood. 2018 Jul 19;132(3)277-280. PMID: 29764839
- Pharmacogenomics of blood lipid regulation. Legault MA*, Tardif JC, Dubé MP. Pharmacogenomics. 2018 May;19(7):651-665. PMID: 29706123
- A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure. Denus S, Dubé MP, Fouodjio R*, Huynh T, LeBlanc MH, Lepage S, Sheppard R, Giannetti N, Lavoie J, Mansour A, Provost S*, Normand V, Mongrain I*, Langlois M*, O'Meara E, Ducharme A, Racine N, Guertin MC, Turgeon J, Phillips MS, Rouleau JL, Tardif JC, White M; CANDIID II investigators. Pharmacogenomics. 2018 May;19(7):599-612. PMID: 29701105
- Rationale, design and preliminary results of the Quebec Warfarin Cohort Study. Perreault S, Shahabi P*, Côté R, Dumas S*, Rouleau-Mailloux É*, Feroz Zada Y*, Provost S*, Mongrain I*, Dorais M, Huynh T, Kouz S, Diaz A, Blostein M, de Denus S, Turgeon J, Ginsberg J, Lelorier J, Lalonde L, Busque L, Kassis J, Talajic M, Tardif JC, Dubé MP. Clin Cardiol. 2018 May;41(5):576-585 PMID: 29542828
- Exome-wide association study of plasma lipids in >300,000 individuals. Liu DJ, …, Kathiresan S. Nat Genet. 2017 Dec;49(12):1758-1766, PMID: 29083408
- CKing Precision in the Interpretation of Diagnostic Biomarkers. de Denus S, Tardif JC, Dubé MP. Circ Cardiovasc Genet. 2017 Aug;10(4). pii: e001874. PMID: 28790156
- DNMT3A and TET2 dominate clonal hematopoiesis, demonstrate benign phenotypes and different genetic predisposition. Buscarlet M, Provost S*, Feroz Zada Y*, Barhdadi A*, Bourgoin V, Lépine G, Mollica L, Szuber N, Dubé MP, Busque L. Blood. 2017 Aug 10;130(6):753-762, PMID: 28655780
- CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. de Denus S, Rouleau JL, Mann DL, Huggins GS, Pereira NL, Shah SH, Cappola TP, Fouodjio R*, Mongrain I*, Dubé MP. Pharmacogenomics J. 2018 Apr;18(2) :232-237. PMID: 28440343
- genipe: An automated genome-wide imputation pipeline with automatic reporting and statistical tools. Lemieux Perreault LP*, Legault MA*, Asselin G*, Dubé MP. Bioinformatics. 2016, 32(23): 3661-3663 PMID: 27497439
- Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Postmus I, …, Krauss RM. J Med Genet. 2016 Dec;53(12):835-845. PMID: 27587472
- Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance with Clinical Outcomes. Tardif JC, Rhainds D, Brodeur M, Feroz Zada Y*, Fouodjio R*, Provost S*, Boulé M, Alem S, Grégoire JC, L'Allier PL, Ibrahim R, Guertin MC, Mongrain I*, Olsson AG, Schwartz GG, Rhéaume É, Dubé MP. Circ Cardiovasc Genet. 2016 Aug;9(4):340-8. PMID: 27418594
- Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. Myocardial Infarction Genetics CARDIoGRAM Exome Consortia Investigators: Stitziel NO, …, Schunker H. New England Journal of Medicine, March 24; 374(12):1134-44, 2016. PMID: 26934567
- A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of 3 clinical trials. de Denus S, Rouleau J, Mann D, Huggins G, Cappola T, Shah S, Keleti J, Feroz Zada Y*, Provost S*, Barhdadi A*, Phillips M, Normand V*, Mongrain I*, Dubé MP. Pharmacogenomics J. 2016 Mar;17(2):192-200 PMID: 26927285
- Pharmacogenomics to Revive Drug Development in Cardiovascular Disease. Dubé MP, de Denus S, Tardif JC. Cardiovascular Drugs and Therapy, 2016 Feb;30(1):59-64; PMID: 26768480
- Impact of regular physical activity on weekly warfarin dose requirement. Rouleau-Mailloux É*, Shahabi P*, Dumas S*, Feroz Zada Y*, Provost S*, Hu J*, Nguyen J*, Bouchama N*, Mongrain I*, Talajic M, Tardif JC, Perreault S, Dubé MP. J Thromb Thrombolysis. 2016 Feb;41(2):328-35, PMID: 26238769
- Pharmacogenomic Determinants of the Cardiovascular Effects of Dalcetrapib. Tardif JC, Rhéaume E, Lemieux Perreault LP*, Grégoire JC, Feroz Zada Y*, Asselin G*, Provost S*, Barhdadi A*, Rhainds D, L’Allier PL, Ibrahim R, Upmanyu R, Niesor EJ, Benghozi R, Suchankova G, Laghrissi-Thode F, Guertin MC, Olsson AG, Mongrain I*, Schwartz GG, Dubé MP. Circ Cardiovasc Genet, 2015 Apr;8(2):372-82; PMID: 25583994
H-index = 52
Liste complète des publiations : https://scholar.google.com.au/citations?user=Yz1gObIAAAAJ&hl=en&oi=ao
Communications Expand all Collapse all
- La génétique et les médicaments. TEDx Pôle Maisonneuve, published online on Dec 21 2016.
- Can Medicine be Personalized Without Sex and Gender. Featured Research. Canadian Institutes of Health Research, Institute Gender and Health. Interviewed by Rachel MacNeil. First published August 2016.
- Marie-Pierre Dubé: une femme de défis. Portraits de chercheurs (Recherchers’ profiles), published by the Université de Montréal, appears online and was distributed to the broad university community. Interviewed by Annik Chainey. First published June 2015.
- La pilule aux yeux bleus. Les années lumière. Weekly science radio program on Ici Radio-Canada. Interviewed by Yannick Villedieu. First broadcast February 2009.
- Des médicaments sur mesure pour chaque patient ? Les promesses de la pharmacogénomique. Le Code Chastenay, Télé-Québec, Émission #7. Interview given as part of a televised documentary science series, aired for the first time February 18 2008. Interviewed by Véronique Morin.
Additional Information
- Équipe de recherche de Marie-Pierre Dubé
- Centre de Pharmacogénomique Beaulieu-Saucier de l'Université de Montréal
- 2015-01-13 Première mondiale : découverte d'une thérapie personnalisée pour les maladies cardiovasculaires
- Portrait de chercheur - Marie-Pierre Dubé : une femme de défis
- 29-10-2014 L'effet des statines influencé par le profil génétique
Media
Portrait de chercheur : Dre Marie-Pierre Dubé 1/2
Portrait de chercheur : Dre Marie-Pierre Dubé 2/2
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